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The molecule was advanced into clinical development by the Croatian pharmaceutical company Pliva under the designations PL-10, PLD-116, and PL 14736 for inflammatory bowel disease research

Influence of the normal flora on mucosal morphology and cellular renewal in the ileum

While the positive ions will help toxins release through the feet, the presence of negative ions in the body mainly works to help the body rid itself of toxins through normal physiological processes, such as urination, defecation, and perspiration

Since inflammation of the large intestine affects brain function through braingut interaction, patients with colitis are at a high risk of developing psychiatric disorders, such as depression and anxiety, during the exacerbation period 43,44